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KMID : 1200020130370040252
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Diabetes & Metabolism Journal
2013 Volume.37 No. 4 p.252 ~ p.261
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Serum Adiponectin and Type 2 Diabetes: A 6-Year Follow-Up Cohort Study
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Jee Sun-Ha
Ahn Chul-Woo
Park Jong-Suk
Park Chang-Gyu
Kim Hyon-Suk
Lee Sang-Hak
Park Sung-Ha
Lee Myoung-Sook
Lee Chang-Beom
Park Hye-Soon
Kimm Hee-Jin
Choi Sung-Hee
Sung Ji-Dong
Oh Seung-Joon
Joung Hyo-Jee
Kim Sung-Rae
Kim Sun-Mi
Youn Ho-Joong
Lee Hong-Soo
Mok Ye-Jin
Choi Eun-Mi
Yun Young-Duk
Baek Soo-Jin
Jo Jae-Seong
Huh Kap-Bum
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Abstract
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Background: Studies on factors which may predict the risk of diabetes are scarce. This prospective cohort study was conducted to determine the association between adiponectin and type 2 diabetes among Korean men and women.
Methods: A total of 42,845 participants who visited one of seven health examination centers located in Seoul and Gyeonggi province, Republic of Korea between 2004 and 2008 were included in this study. The incidence rates of diabetes were determined through December 2011. To evaluate the effects of adiponectin on type 2 diabetes, the Cox proportional hazard model was used.
Results: Of the 40,005 participants, 959 developed type 2 diabetes during a 6-year follow-up. After the adjustment for age, body mass index (BMI), and waist circumference, the risks for type 2 diabetes in participants with normoglycemia had a 1.70-fold (95% confidence interval [CI], 1.21 to 2.38) increase in men and a 1.83-fold (95% CI, 1.17 to 2.86) increase in women with the lowest tertile of adiponectin when compared to the highest tertile of adiponectin. For participants with impaired fasting glucose (IFG), the risk for type 2 diabetes had a 1.46-fold (95% CI, 1.17 to 1.83) increase in men and a 2.52-fold (95% CI, 1.57 to 4.06) increase in women with the lowest tertile of adiponectin. Except for female participants with normoglycemia, all the risks remained significant after the adjustment for fasting glucose and other confounding variables. Surprisingly, BMI and waist circumference were not predictors of type 2 diabetes in men or women with IFG after adjustment for fasting glucose and other confounders.
Conclusion: A strong association between adiponectin and diabetes was observed. The use of adiponectin as a predictor of type 2 diabetes is considered to be useful.
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KEYWORD
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Adiponectin, Cohort studies, Diabetes mellitus, Impaired fasting glucose
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